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兒茶素預防一般常見疾病
A New Function of Green Tea: Prevention of Lifestyle-related Diseases
NAOKO SUEOKA, MASAMI SUGANUMA, EISABURO SUEOKA,SACHIKO OKABE, SATORU MATSUYAMA, KAZUE IMAI, KEI NAKACHI, AND HIROTA FUJIKI
Saitama Cancer Center Research Institute, Ina, Kitaadachi-gun,
Saitama 362-0806, Japan
ABSTRACT: In the normal human life span, there occur lifestyle-related diseases
that may be preventable with nontoxic agents. This paper deals with the preventive
activity of green tea in some lifestyle-related diseases. Green tea is one
of the most practical cancer preventives, as we have shown in various in vitro
and in vivo experiments, along with epidemiological studies. Among various biological
effects of green tea, we have focused on its inhibitory effect on TNF-
gene expression mediated through inhibition of NF-B and AP-1 activation.
Based on our recent results with TNF--deficient mice, TNF- is an endogenous
tumor promoter. TNF- is also known to be a central mediator in chronic
inflammatory diseases such as rheumatoid arthritis and multiple sclerosis. We
therefore hypothesized that green tea might be a preventive agent for chronic
inflammatory diseases. To test this hypothesis, TNF- transgenic mice, which
overexpress TNF- only in the lungs, were examined. The TNF- transgenic
mouse is an animal model of human idiopathic pulmonary fibrosis which also
frequently develops lung cancer. Expressions of TNF- and IL-6 were inhibited
in the lungs of these mice after treatment with green tea in drinking water for
4 months. In addition, judging from the results of a prospective cohort study in
Saitama Prefecture, Japan, green tea helps to prevent cardiovascular disease.
In this study, a decreased relative risk of death from cardiovascular disease was
found for people consuming over 10 cups of green tea a day, and green tea also
had life-prolonging effects on cumulative survival. These data suggest that
green tea has preventive effects on both chronic inflammatory diseases and
lifestyle-related diseases (including cardiovascular disease and cancer), resulting
in prolongation of life span
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